| | | Tuesday, May 10th, 2022 | | Signed free agent C Homer Bryan to a 1-year contract worth a total of $1,400,000. |
| Sunday, March 6th, 2022 | | Signed free agent 2B Domingo Mendoza to a minor league contract. |
| Thursday, February 3rd, 2022 | | Signed free agent SP Deangelo Ceja to a 5-year contract worth a total of $155,500,000. |
| Wednesday, January 12th, 2022 | | Signed free agent 2B Juan Galindo to a 1-year contract worth a total of $1,400,000. |
| Wednesday, December 22nd, 2021 | | Signed free agent CL Manny Silva to a 2-year contract worth a total of $8,900,000. |
| Tuesday, December 21st, 2021 | | Signed free agent SP Leonard Carter to a minor league contract. |
| Tuesday, December 14th, 2021 | | Signed free agent SP Juan Domínguez to a minor league contract. |
| Sunday, November 28th, 2021 | | CF Carlos Montoya received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Brendan Kane received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Adam Berry becomes a free-agent. | | C Troy Bloomingdale received a 1-year contract through automatic renewal worth a total of $400,000. | | 3B Joe Chatwin received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Ryan Thomas received a 1-year contract through automatic renewal worth a total of $410,000. | | CF Martin Robinson received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Dylan King received a 1-year contract through automatic renewal worth a total of $400,000. | | CF Kelly Malkin received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Brian Woods received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Won Sun received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Steven Hanson becomes a free-agent. | | MR Lúcio Gavcia becomes a free-agent. | | MR Stu Mayer becomes a free-agent. | | SP Owen Stuart becomes a free-agent. | | 2B Alex Oliver becomes a free-agent. | | LF Kel Wilson becomes a free-agent. | | CF José Menéndez becomes a free-agent. |
| Thursday, November 25th, 2021 | | C Tomokazu Ine received a 1-year contract through arbitration worth a total of $1,000,000. | | SS Martin Burns becomes a free-agent. | | MR Carlos Aguilar received a 1-year contract through arbitration worth a total of $3,555,500. | | 1B Ryan Christian becomes a free-agent. | | LF Joe Perkins received a 1-year contract through arbitration worth a total of $1,176,000. | | CF Gil Cahill becomes a free-agent. | | 3B Ron McCall received a 1-year contract through arbitration worth a total of $600,000. | | MR Robbie Finch becomes a free-agent. | | 2B Alvin Stokes received a 1-year contract through arbitration worth a total of $600,000. |
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