| | | Thursday, May 12th, 2022 | | Signed SS Tyson Chapman to a 2-year contract extension worth a total of $7,680,000. |
| Monday, April 25th, 2022 | | Placed RF Freddie Young on the 14-day disabled list. | | Placed LF Tom Dares on the 40-man roster. | | Placed LF Tom Dares on the active roster. |
| Monday, April 18th, 2022 | | Placed LF Tom Dares on the 40-man roster. | | LF Tom Dares was designated for assignment and placed on waivers. |
| Saturday, April 16th, 2022 | | Signed C Luis Cantú to a minor league contract extension. | | Signed SP Charles Blair to a minor league contract extension. |
| Monday, April 4th, 2022 | | Signed CF Ray Long to a 3-year contract extension worth a total of $24,400,000. |
| Thursday, March 10th, 2022 | | Signed CL Ron Orr to a 2-year contract extension worth a total of $16,000,000. |
| Tuesday, March 8th, 2022 | | Signed CL Clarence Marshall to a minor league contract extension. |
| Monday, March 7th, 2022 | | Signed C Pancho Hernández to a minor league contract extension. |
| Sunday, March 6th, 2022 | | Signed 1B Tony Hudson to a 1-year contract extension worth a total of $1,100,000. |
| Sunday, December 19th, 2021 | | Signed free agent 2B Brent Carter to a minor league contract. |
| Wednesday, December 15th, 2021 | | Signed free agent 1B Ash Wilson to a minor league contract. |
| Sunday, December 12th, 2021 | | Signed free agent LF David Horton to a minor league contract. |
| Friday, December 10th, 2021 | | Signed free agent C Pancho Hernández to a minor league contract. |
| Wednesday, December 8th, 2021 | | Signed free agent C Luis Cantú to a minor league contract. |
| Sunday, November 28th, 2021 | | 3B Curtis Downing received a 1-year contract through automatic renewal worth a total of $400,000. | | C Rolland Minor becomes a free-agent. | | 3B Dale Hayes becomes a free-agent. | | 1B William Jordan becomes a free-agent. | | CF Thomas Garrett becomes a free-agent. | | 2B Shane Nance becomes a free-agent. | | SP Judd Watts becomes a free-agent. | | C Joe Barnard becomes a free-agent. | | MR Ramón Liendo received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Tim Cain received a 1-year contract through automatic renewal worth a total of $400,000. | | 2B Terrance Johnson received a 1-year contract through automatic renewal worth a total of $400,000. | | 2B José Blanco received a 1-year contract through automatic renewal worth a total of $400,000. | | Placed SP William Jordan on the 40-man roster. | | C Yifu Ya becomes a free-agent. |
| Thursday, November 25th, 2021 | | SP Justin Thompson received a 1-year contract through arbitration worth a total of $900,000. | | CF Ray Long received a 1-year contract through arbitration worth a total of $7,500,500. | | CL Ron Orr received a 1-year contract through arbitration worth a total of $7,500,000. | | SS Dean Aldridge received a 1-year contract through arbitration worth a total of $1,420,000. | | MR Billy O'Neal received a 1-year contract through arbitration worth a total of $2,187,000. | | SP William Douglas received a 1-year contract through arbitration worth a total of $2,800,000. | | RF Freddie Young received a 1-year contract through arbitration worth a total of $6,126,000. | | LF Tom Dares received a 1-year contract through arbitration worth a total of $1,650,000. | | RF Héctor Mendoza received a 1-year contract through arbitration worth a total of $1,050,000. | | MR Jake Bailey received a 1-year contract through arbitration worth a total of $600,000. | | 1B Tony Hudson received a 1-year contract through arbitration worth a total of $1,020,000. |
| Friday, November 5th, 2021 | | Signed SP Oki Okada to a 5-year contract extension worth a total of $65,500,000. |
| Tuesday, September 7th, 2021 | | Placed CF Thomas Garrett on the active roster. |
| Saturday, July 24th, 2021 | | Signed MR Jason Lambert to a 2-year contract extension worth a total of $13,820,000. |
| Thursday, July 22nd, 2021 | | Signed RF Travis Wright to a 4-year contract extension worth a total of $79,600,000. |
| Saturday, July 17th, 2021 | | Signed Tim Lewis to a minor league contract with a signing bonus of $980,000. |
| Friday, July 16th, 2021 | | Signed Eduardo Rivera to a minor league contract with a signing bonus of $910,000. |
| Thursday, July 15th, 2021 | | Signed Terrance Johnson to a minor league contract with a signing bonus of $1,310,000. | | Signed Harry Gillingham to a minor league contract with a signing bonus of $190,000. |
| Wednesday, July 14th, 2021 | | Signed free agent CF Raúl Alomar to a minor league contract. |
| Sunday, July 11th, 2021 | | Signed John Turner to a minor league contract with a signing bonus of $180,000. |
| Saturday, July 10th, 2021 | | Signed 1B Danny Rodgers to a minor league contract extension. | | Signed RF Kip Thompson to a minor league contract extension. | | Signed Jay Brown to a minor league contract with a signing bonus of $260,000. |
| Wednesday, July 7th, 2021 | | Signed Hugo Ávila to a minor league contract with a signing bonus of $1,700,000. |
| Monday, July 5th, 2021 | | Placed 3B Jason Wallace on the SIMBL A League 7-day disabled list. |
| Thursday, June 17th, 2021 | | Signed CF Vitaliano Nardello to a minor league contract extension. |
| Tuesday, June 15th, 2021 | | Drafted 2B Terrance Johnson in the 2021 first-year player draft (Round 1, Pick 16, 16th overall pick). | | Drafted C Tim Lewis in the 2021 first-year player draft (Supplemental Round 1, Pick 15, 39th overall pick). | | Drafted CL Hugo Ávila in the 2021 first-year player draft (Supplemental Round 1, Pick 18, 42nd overall pick). | | Drafted 2B Eduardo Rivera in the 2021 first-year player draft (Round 2, Pick 16, 58th overall pick). | | Drafted LF Jay Brown in the 2021 first-year player draft (Round 3, Pick 19, 85th overall pick). | | Drafted RF John Turner in the 2021 first-year player draft (Round 4, Pick 24, 120th overall pick). | | Drafted 3B Harry Gillingham in the 2021 first-year player draft (Round 5, Pick 23, 152nd overall pick). | | Drafted RF Herb Clark in the 2021 first-year player draft (Round 6, Pick 16, 180th overall pick). | | Drafted SP Dave White in the 2021 first-year player draft (Round 7, Pick 16, 204th overall pick). | | Drafted 1B Donald Thompson in the 2021 first-year player draft (Round 8, Pick 16, 228th overall pick). | | Drafted C Phil McClure in the 2021 first-year player draft (Round 9, Pick 16, 252nd overall pick). | | Drafted 1B Raul Alfaro in the 2021 first-year player draft (Round 10, Pick 16, 276th overall pick). |
| Tuesday, May 25th, 2021 | | Signed free agent CF Thomas Garrett to a 1-year contract worth a total of $500,000. |
| Thursday, April 1st, 2021 | | Signed SP William Jordan to a 1-year contract extension worth a total of $400,000. |
| Saturday, February 6th, 2021 | | Signed free agent MR Daniel Lutz to a 2-year contract worth a total of $16,800,000. | | Signed free agent SP Ryan Mays to a 2-year contract worth a total of $14,580,000. |
| Friday, February 5th, 2021 | | Signed free agent MR Vance McElroy to a 2-year contract worth a total of $5,660,000. |
| Sunday, November 29th, 2020 | | SP Oki Okada received a 1-year contract through automatic renewal worth a total of $410,000. | | SP Justin Thompson received a 1-year contract through automatic renewal worth a total of $410,000. | | MR Brit Frost received a 1-year contract through automatic renewal worth a total of $400,000. | | SS Dean Aldridge received a 1-year contract through automatic renewal worth a total of $410,000. | | MR Daniel Lutz becomes a free-agent. | | SP Ashton Austin becomes a free-agent. | | MR Billy O'Neal received a 1-year contract through automatic renewal worth a total of $410,000. | | LF Tom Dares received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Ramón Liendo received a 1-year contract through automatic renewal worth a total of $400,000. | | MR David Butler received a 1-year contract through automatic renewal worth a total of $400,000. | | 3B Curtis Downing received a 1-year contract through automatic renewal worth a total of $400,000. | | SS Ray Miller received a 1-year contract through automatic renewal worth a total of $400,000. | | RF Paul Cook becomes a free-agent. | | RF Wing-chiu Wang becomes a free-agent. | | C Jorge Hernández becomes a free-agent. | | SP Sandy Davenport becomes a free-agent. | | MR Gary Evans becomes a free-agent. | | MR Jeff Surles becomes a free-agent. |
| Thursday, November 26th, 2020 | | CF Ray Long received a 1-year contract through arbitration worth a total of $7,500,500. | | CL Ron Orr received a 1-year contract through arbitration worth a total of $7,000,000. | | C Rolland Minor received a 1-year contract through arbitration worth a total of $12,500,000. | | RF Héctor Mendoza received a 1-year contract through arbitration worth a total of $1,000,000. | | MR Jake Bailey received a 1-year contract through arbitration worth a total of $600,000. | | 1B Tony Hudson received a 1-year contract through arbitration worth a total of $1,020,000. |
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