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| Career Post-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts | PA | Years | Single Season Leaderboard |
| 1. | Kenny Blumberg | 68 | 252 | 2009-2012 | |
| 2. | Walker McElfresh | 61 | 268 | 2009-2014 | |
| 3. | Daryl Ryles | 60 | 396 | 2009-2014 | |
| 4. | Serafin Fradera | 59 | 237 | 2009-2014 | |
| 5. | Santiago Hernandez | 55 | 275 | 2010-2014 | |
| Jeremy Phillips | 55 | 230 | 2010-2014 | ||
| 7. | Leroy Mankin | 50 | 153 | 2009-2014 | |
| Hayden Bandy | 50 | 239 | 2009-2012 | ||
| 9. | Jose Zena | 49 | 165 | 2009-2012 | |
| 10. | Horacio Diaz | 48 | 239 | 2009-2012 | |
| 11. | Buster Tate | 47 | 195 | 2010-2014 | |
| 12. | Lucas Espitia | 46 | 410 | 2009-2014 | |
| 13. | Cane Wilson | 44 | 189 | 2010-2013 | |
| 14. | Allen Hepner | 43 | 187 | 2009-2014 | |
| 15. | Douglas Linsley | 42 | 234 | 2009-2012 | |
| 16. | Mathew Skinner | 41 | 223 | 2010-2014 | |
| Ernest Crivello | 41 | 155 | 2009-2014 | ||
| Luis Franco | 41 | 151 | 2009-2013 | ||
| 19. | Taitarou Haranobu | 40 | 210 | 2011-2014 | |
| 20. | Keith Smith | 39 | 176 | 2011-2014 | |
| 21. | Wilfredo Gonzalez | 38 | 192 | 2009-2012 | |
| 22. | Joseph Montoya | 37 | 187 | 2010-2013 | |
| 23. | Emil Villarreal | 35 | 155 | 2010-2014 | |
| Alejo Ramirez | 35 | 195 | 2009-2011 | ||
| Alberto Andrade | 35 | 159 | 2009-2011 | ||
| 26. | Bill Falco | 34 | 139 | 2009-2012 | |
| 27. | Omar Velazquez | 33 | 139 | 2010-2014 | |
| Mario Botella | 33 | 159 | 2009-2011 | ||
| 29. | Bernard Sanchez | 32 | 159 | 2012-2014 | |
| Robt Wedge | 32 | 135 | 2010-2012 | ||
| 31. | Wesley Almeida | 31 | 172 | 2011-2014 | |
| John Rupe | 31 | 137 | 2009-2013 | ||
| Manny Martinez | 31 | 242 | 2009-2012 | ||
| 34. | Richard Cummings | 30 | 223 | 2010-2014 | |
| Michael Quiros | 30 | 181 | 2012-2014 | ||
| David Speight | 30 | 158 | 2010-2012 | ||
| 37. | Adam Wells | 29 | 235 | 2009-2014 | |
| Eddie House | 29 | 123 | 2009-2014 | ||
| John Mitchell | 29 | 124 | 2010-2013 | ||
| Willie Sullivan | 29 | 151 | 2009-2012 | ||
| 41. | Guy Gillham | 28 | 175 | 2010-2012 | |
| 42. | Bruce Lorenzo | 27 | 212 | 2009-2014 | |
| Sang Aleshire | 27 | 124 | 2009-2014 | ||
| Javier Amezaga | 27 | 106 | 2009-2012 | ||
| 45. | Ray Barrot | 25 | 91 | 2011-2013 | |
| 46. | Kevin Yuko | 23 | 139 | 2009-2014 | |
| Eugene Pelzer | 23 | 110 | 2009-2014 | ||
| 48. | John Strasser | 22 | 95 | 2010-2014 | |
| William Bourland | 22 | 79 | 2009-2014 | ||
| Palmer Amico | 22 | 87 | 2009-2013 |
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