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| Single-Season Losses Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Losses | IP | Year | Career Leaderboard |
| 1. | Anthony Mann | 26 | 189.0 | 2013 | |
| 2. | Numbers Greening | 24 | 214.3 | 2014 | |
| 3. | Joesph Kestner | 23 | 246.7 | 2012 | |
| 4. | Xavier Castillo | 22 | 244.7 | 2014 | |
| John Hammock | 22 | 206.7 | 2011 | ||
| Ben Morelli | 22 | 223.7 | 2009 | ||
| 7. | Jamal Walker | 21 | 232.3 | 2014 | |
| Roy Bourbeau | 21 | 244.0 | 2012 | ||
| 9. | Eric Waddington | 20 | 235.3 | 2012 | |
| James Lubin | 20 | 216.0 | 2009 | ||
| 11. | Joseph Davis | 19 | 211.7 | 2014 | |
| Frank Bareche Jr. | 19 | 186.0 | 2014 | ||
| Craig Moyers | 19 | 159.3 | 2014 | ||
| Jamal Walker | 19 | 239.7 | 2013 | ||
| Ronald Williams | 19 | 233.0 | 2013 | ||
| Walter Fernandez | 19 | 214.0 | 2013 | ||
| Baldo Astudillo | 19 | 182.0 | 2012 | ||
| Gerald Orduna | 19 | 228.7 | 2011 | ||
| Andrew Pennell | 19 | 197.3 | 2011 | ||
| Benito Baeza | 19 | 145.3 | 2011 | ||
| Christopher Sweet | 19 | 201.0 | 2010 | ||
| Paul Cevallos | 19 | 186.3 | 2010 | ||
| Robert Elms | 19 | 207.0 | 2009 | ||
| 24. | Clinton Ross | 18 | 242.3 | 2014 | |
| Bill Hightower | 18 | 240.0 | 2014 | ||
| James Hockensmith | 18 | 214.7 | 2014 | ||
| George Anderson | 18 | 207.3 | 2013 | ||
| Clifford Kikaku | 18 | 196.0 | 2013 | ||
| Carlos Molina | 18 | 237.7 | 2012 | ||
| Clifford Kikaku | 18 | 228.7 | 2012 | ||
| Alexander Miller | 18 | 206.7 | 2012 | ||
| Ronald Koenig | 18 | 205.7 | 2011 | ||
| Ramon Mota | 18 | 131.0 | 2011 | ||
| Ricardo Manzanares | 18 | 129.0 | 2010 | ||
| Doyle Brunette | 18 | 188.3 | 2009 | ||
| 36. | Floyd Collins | 17 | 226.7 | 2014 | |
| Danial Hayes | 17 | 198.7 | 2014 | ||
| Walter Fernandez | 17 | 172.3 | 2014 | ||
| Joseph Tutor | 17 | 234.3 | 2013 | ||
| Michael Arnold | 17 | 211.3 | 2013 | ||
| Baldo Astudillo | 17 | 183.0 | 2013 | ||
| Andrew Pennell | 17 | 188.7 | 2012 | ||
| Pierre Sandoval | 17 | 236.3 | 2011 | ||
| Constantino Aranda | 17 | 206.7 | 2011 | ||
| Bobby Currey | 17 | 202.0 | 2011 | ||
| Ted Sayer | 17 | 199.7 | 2010 | ||
| Rick Varney | 17 | 227.0 | 2009 | ||
| Carlos Molina | 17 | 215.0 | 2009 | ||
| 49. | Deangelo Ceja | 16 | 248.0 | 2014 | |
| Joseph Tutor | 16 | 223.3 | 2014 | ||
| Don Tsuyoshi | 16 | 175.0 | 2014 | ||
| Eric Alba | 16 | 239.7 | 2013 | ||
| John McCasland | 16 | 199.0 | 2013 | ||
| Peter Calvillo | 16 | 149.3 | 2013 | ||
| Steven Remick | 16 | 130.3 | 2013 | ||
| Joel Schacher | 16 | 116.0 | 2013 | ||
| Casey George | 16 | 227.7 | 2012 | ||
| James Volkert | 16 | 200.0 | 2012 | ||
| Danial Hayes | 16 | 198.0 | 2012 | ||
| Ramon Medina | 16 | 212.0 | 2011 | ||
| Israel Mitchell | 16 | 206.3 | 2011 | ||
| Justo Rubio | 16 | 196.3 | 2011 | ||
| Kevin Ledet | 16 | 188.3 | 2011 | ||
| Baldo Astudillo | 16 | 106.3 | 2011 | ||
| Carlos Molina | 16 | 251.3 | 2010 | ||
| Rick Varney | 16 | 221.0 | 2010 | ||
| Alfredo Salazar | 16 | 220.0 | 2010 | ||
| Casey George | 16 | 219.3 | 2010 | ||
| Augustine Perez | 16 | 184.0 | 2010 | ||
| Roman Peņa | 16 | 182.3 | 2010 | ||
| Lee Minnick | 16 | 128.3 | 2010 | ||
| David Erickson | 16 | 234.3 | 2009 | ||
| Celso Larios | 16 | 225.3 | 2009 | ||
| Jacinto Diaz | 16 | 195.3 | 2009 | ||
| Edwin Thacker | 16 | 191.7 | 2009 | ||
| 76. | Vernan Powell | 15 | 233.3 | 2014 | |
| Joe Laubach | 15 | 225.3 | 2014 | ||
| Gerald Orduna | 15 | 214.7 | 2014 | ||
| Michael Arnold | 15 | 209.3 | 2014 | ||
| Larry Ensminger | 15 | 157.3 | 2014 | ||
| Bill Hightower | 15 | 263.3 | 2013 | ||
| John McClary | 15 | 253.0 | 2013 | ||
| Pedro Galindo | 15 | 242.3 | 2013 | ||
| Benito Herrera | 15 | 233.3 | 2013 | ||
| Kevin Whitford | 15 | 203.7 | 2013 | ||
| Josue Moniz | 15 | 201.7 | 2013 | ||
| Jerome Tunnell | 15 | 195.3 | 2013 | ||
| Mario Fung | 15 | 158.0 | 2013 | ||
| Joe Laubach | 15 | 235.0 | 2012 | ||
| Walter Sanchez | 15 | 198.3 | 2012 | ||
| Ernesto Nazario | 15 | 194.0 | 2012 | ||
| Jerome Tunnell | 15 | 193.7 | 2012 | ||
| Sam Glisson | 15 | 184.0 | 2012 | ||
| Joel Schacher | 15 | 181.3 | 2012 | ||
| Israel Mitchell | 15 | 177.0 | 2012 | ||
| Thomas Leverett | 15 | 227.0 | 2011 | ||
| Casey George | 15 | 222.7 | 2011 | ||
| David Erickson | 15 | 215.0 | 2011 | ||
| Peter Calvillo | 15 | 212.7 | 2011 | ||
| Paul Williams | 15 | 209.7 | 2011 |
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