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| Second Basemen Single-Season Homeruns Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Homeruns | PA | Year | Career Leaderboard |
| 1. | Duane Fuller | 35 | 677 | 2014 | |
| 2. | Daniel Walker | 31 | 685 | 2010 | |
| 3. | Alberto Andrade | 28 | 655 | 2010 | |
| 4. | Daniel Blaha | 25 | 658 | 2009 | |
| 5. | Steven Cameron | 23 | 645 | 2013 | |
| Harold Bates | 23 | 620 | 2013 | ||
| Jeremy Phillips | 23 | 644 | 2012 | ||
| Daniel Blaha | 23 | 676 | 2011 | ||
| Lucas Espitia | 23 | 727 | 2009 | ||
| Alberto Andrade | 23 | 634 | 2009 | ||
| 11. | Lucas Espitia | 22 | 718 | 2010 | |
| Andres Herrera | 22 | 708 | 2009 | ||
| 13. | Daniel Walker | 21 | 545 | 2009 | |
| 14. | Lucas Espitia | 20 | 722 | 2011 | |
| 15. | Michael Larson | 19 | 726 | 2014 | |
| Paul Mielke | 19 | 683 | 2014 | ||
| Charles Stanhope | 19 | 649 | 2014 | ||
| Raimundo Ramirez | 19 | 585 | 2012 | ||
| Richard Mowers | 19 | 647 | 2011 | ||
| Michael Larson | 19 | 661 | 2010 | ||
| 21. | Arnold Harkins | 18 | 650 | 2014 | |
| Daniel Walker | 18 | 645 | 2012 | ||
| Jeremy Phillips | 18 | 651 | 2011 | ||
| Arnold Harkins | 18 | 604 | 2009 | ||
| 25. | Alvin Kelley | 17 | 703 | 2013 | |
| Thomas Grandstaff | 17 | 573 | 2012 | ||
| Alberto Andrade | 17 | 686 | 2011 | ||
| Raimundo Ramirez | 17 | 679 | 2010 | ||
| Rayford Azevedo | 17 | 642 | 2010 | ||
| Ferdy Diaz | 17 | 620 | 2009 | ||
| Tokukichirou Shigematsu | 17 | 490 | 2009 | ||
| 32. | Daniel Walker | 16 | 640 | 2013 | |
| Rayford Azevedo | 16 | 636 | 2012 | ||
| Daniel Walker | 16 | 489 | 2011 | ||
| Daniel Blaha | 16 | 683 | 2010 | ||
| 36. | Daniel Walker | 15 | 606 | 2014 | |
| Stephen Allison | 15 | 602 | 2014 | ||
| Michael Larson | 15 | 704 | 2012 | ||
| Alvin Kelley | 15 | 627 | 2012 | ||
| Michael Larson | 15 | 707 | 2011 | ||
| Ferdy Diaz | 15 | 528 | 2010 | ||
| Randy Crofts | 15 | 470 | 2010 | ||
| Michael Beckley | 15 | 651 | 2009 | ||
| 44. | Jeremy Phillips | 14 | 649 | 2014 | |
| Michael Beckley | 14 | 628 | 2014 | ||
| Lucas Espitia | 14 | 721 | 2013 | ||
| Thomas Grandstaff | 14 | 628 | 2013 | ||
| Michael Beckley | 14 | 579 | 2012 | ||
| Arnold Harkins | 14 | 641 | 2011 | ||
| Ferdy Diaz | 14 | 579 | 2011 | ||
| Kenneth Coghlan | 14 | 689 | 2010 | ||
| Randy Crofts | 14 | 583 | 2009 | ||
| 53. | Jeremy Phillips | 13 | 712 | 2013 | |
| Michael Larson | 13 | 700 | 2013 | ||
| Richard Mowers | 13 | 648 | 2012 | ||
| Michael Beckley | 13 | 689 | 2011 | ||
| Faustino Delmas | 13 | 637 | 2011 | ||
| Randy Crofts | 13 | 470 | 2011 | ||
| Richard Mowers | 13 | 612 | 2010 | ||
| Andres Herrera | 13 | 523 | 2010 | ||
| Jose Luna | 13 | 528 | 2009 | ||
| 62. | Harold Bates | 12 | 548 | 2014 | |
| Herb Wells | 12 | 419 | 2014 | ||
| Rayford Azevedo | 12 | 679 | 2013 | ||
| Lucas Espitia | 12 | 671 | 2012 | ||
| Arnold Harkins | 12 | 600 | 2012 | ||
| Tokukichirou Shigematsu | 12 | 579 | 2012 | ||
| Steven Cameron | 12 | 578 | 2012 | ||
| Ramon Serrano | 12 | 629 | 2010 | ||
| Ramon Serrano | 12 | 703 | 2009 | ||
| 71. | Lucas Espitia | 11 | 731 | 2014 | |
| Steven Cameron | 11 | 664 | 2014 | ||
| Kevin Yuko | 11 | 589 | 2014 | ||
| Herb Wells | 11 | 331 | 2013 | ||
| Harold Bates | 11 | 390 | 2012 | ||
| Jose Luna | 11 | 674 | 2011 | ||
| 77. | Barry Russo | 10 | 567 | 2014 | |
| Michael Beckley | 10 | 636 | 2013 | ||
| Daniel Blaha | 10 | 590 | 2013 | ||
| Alberto Andrade | 10 | 550 | 2013 | ||
| Raimundo Ramirez | 10 | 532 | 2013 | ||
| Rayford Azevedo | 10 | 626 | 2011 | ||
| Raimundo Ramirez | 10 | 586 | 2011 | ||
| Leroy Judah | 10 | 239 | 2011 | ||
| Horace Shockey | 10 | 687 | 2010 | ||
| Michael Beckley | 10 | 663 | 2010 | ||
| Jeremy Phillips | 10 | 554 | 2010 | ||
| Cirilo Garcia | 10 | 550 | 2009 | ||
| 89. | Rayford Azevedo | 9 | 627 | 2014 | |
| Hernan Colomo | 9 | 159 | 2014 | ||
| Daniel Blaha | 9 | 602 | 2012 | ||
| Herb Wells | 9 | 500 | 2011 | ||
| Tokukichirou Shigematsu | 9 | 498 | 2011 | ||
| Jose Luna | 9 | 691 | 2010 | ||
| Kevin Yuko | 9 | 610 | 2010 | ||
| Herb Wells | 9 | 449 | 2010 | ||
| Faustino Delmas | 9 | 447 | 2010 | ||
| Ben Mora | 9 | 491 | 2009 | ||
| Kenneth Coghlan | 9 | 358 | 2009 | ||
| 100. | Larry Galusha | 8 | 281 | 2014 |
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