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| Second Basemen Career Assists Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Assists | IP | Years | Single Season Leaderboard |
| 1. | Ramon Serrano | 2845 | 7539.0 | 2009-2014 | |
| 2. | Lucas Espitia | 2825 | 8190.7 | 2009-2014 | |
| 3. | Daniel Blaha | 2803 | 7710.0 | 2009-2014 | |
| 4. | Michael Beckley | 2667 | 7719.7 | 2009-2014 | |
| 5. | Michael Larson | 2643 | 6921.3 | 2010-2014 | |
| 6. | Rayford Azevedo | 2380 | 6286.7 | 2009-2014 | |
| 7. | Daniel Walker | 2366 | 7192.3 | 2009-2014 | |
| 8. | Arnold Harkins | 2282 | 6552.6 | 2009-2014 | |
| 9. | Jeremy Phillips | 2198 | 6525.0 | 2009-2014 | |
| 10. | Alberto Andrade | 2169 | 6409.3 | 2009-2014 | |
| 11. | Raimundo Ramirez | 2168 | 5955.3 | 2009-2014 | |
| 12. | Faustino Rodarte | 2104 | 5344.7 | 2009-2013 | |
| 13. | Matthew Fout | 1994 | 5478.7 | 2009-2014 | |
| 14. | Tokukichirou Shigematsu | 1752 | 5025.0 | 2009-2013 | |
| 15. | Faustino Delmas | 1750 | 5422.0 | 2010-2014 | |
| 16. | Steven Cameron | 1710 | 4577.3 | 2011-2014 | |
| 17. | Walter Ocejo | 1514 | 3845.3 | 2009-2013 | |
| 18. | Jose Luna | 1478 | 4173.3 | 2009-2013 | |
| 19. | Kevin Yuko | 1475 | 4261.0 | 2009-2014 | |
| 20. | Paul Tapia | 1296 | 3475.7 | 2009-2014 | |
| 21. | Thomas Grandstaff | 1223 | 3316.7 | 2011-2014 | |
| 22. | Glenn Carrozza | 1143 | 3332.6 | 2009-2014 | |
| 23. | Alvin Kelley | 1136 | 3208.3 | 2009-2013 | |
| 24. | Malcom Acevedo | 1094 | 3173.3 | 2009-2014 | |
| 25. | Jl Perez | 1035 | 3172.7 | 2010-2014 | |
| 26. | Harold Bates | 1033 | 3204.3 | 2012-2014 | |
| 27. | Kenneth Coghlan | 998 | 2812.7 | 2009-2012 | |
| 28. | Antonio Escarcega | 953 | 2489.3 | 2009-2014 | |
| 29. | Ferdy Diaz | 864 | 2471.0 | 2009-2012 | |
| 30. | Andres Herrera | 836 | 2374.7 | 2009-2010 | |
| 31. | Frederick Celestin | 821 | 2552.0 | 2009-2014 | |
| 32. | Horace Shockey | 819 | 2553.7 | 2009-2013 | |
| 33. | Antonio Flores | 746 | 2110.3 | 2009-2013 | |
| 34. | Ben Mora | 684 | 2083.3 | 2009-2014 | |
| 35. | Oswaldo Basaldua | 633 | 1771.3 | 2009-2013 | |
| 36. | Edward Vizcaino | 596 | 1425.0 | 2009-2012 | |
| 37. | Kurt Hudson | 540 | 1660.7 | 2011-2014 | |
| 38. | Paul Mielke | 539 | 1539.7 | 2013-2014 | |
| 39. | John Blagg | 499 | 1457.0 | 2011-2014 | |
| 40. | Charles Stanhope | 471 | 1271.3 | 2013-2014 | |
| 41. | Ronaldo Triado | 449 | 1253.7 | 2009-2010 | |
| 42. | Cirilo Garcia | 433 | 1172.0 | 2009-2010 | |
| 43. | Duane Fuller | 419 | 1320.3 | 2014-2014 | |
| 44. | Herb Wells | 406 | 1224.0 | 2010-2014 | |
| 45. | Kenneth Downey | 403 | 1094.3 | 2014-2014 | |
| 46. | Leroy Mankin | 400 | 1126.0 | 2009-2014 | |
| 47. | Nathan Meidinger | 396 | 1018.3 | 2009-2011 | |
| 48. | Tony Stolp | 383 | 1049.7 | 2012-2014 | |
| 49. | Juan Santillo | 361 | 1152.7 | 2009-2010 | |
| 50. | Kevin Nicastro | 341 | 1003.7 | 2009-2012 | |
| 51. | Marcos Palacios | 337 | 1068.0 | 2009-2013 | |
| 52. | Richard Mowers | 323 | 948.3 | 2010-2014 | |
| 53. | Kerry Clooney | 319 | 911.6 | 2009-2011 | |
| 54. | James Gould | 311 | 922.0 | 2012-2014 | |
| 55. | Hernan Colomo | 294 | 893.7 | 2013-2014 | |
| 56. | Juan Salo | 291 | 749.7 | 2010-2014 | |
| 57. | Ralph Turner | 282 | 852.7 | 2014-2014 | |
| 58. | Ariel Gonzalez | 280 | 772.7 | 2009-2012 | |
| 59. | Matthew Estabrook | 264 | 681.7 | 2009-2013 | |
| 60. | Ricky Williams | 254 | 734.7 | 2009-2013 | |
| 61. | Barry Russo | 249 | 678.3 | 2013-2014 | |
| 62. | Valentine Turbeville | 245 | 601.7 | 2011-2013 | |
| 63. | Scott Haubrich | 237 | 633.7 | 2009-2014 | |
| 64. | Jeremy Bevill | 235 | 616.7 | 2009-2014 | |
| 65. | Ralph Fuller | 234 | 692.7 | 2009-2011 | |
| 66. | Stephen Allison | 216 | 570.3 | 2014-2014 | |
| 67. | Huey Primm | 206 | 554.3 | 2009-2014 | |
| 68. | Romeo Rodriguez | 198 | 585.0 | 2009-2011 | |
| 69. | Larry Simmons | 191 | 530.7 | 2011-2014 | |
| 70. | Javier Amezaga | 184 | 566.3 | 2009-2014 | |
| 71. | Willie Velazquez | 183 | 620.7 | 2011-2014 | |
| Leroy Judah | 183 | 552.3 | 2010-2012 | ||
| 73. | Eric Farthing | 174 | 425.0 | 2010-2010 | |
| 74. | Erubiel Vela | 170 | 491.3 | 2010-2014 | |
| 75. | Jose Arenas | 165 | 430.0 | 2012-2014 | |
| 76. | Pedro Carrasquillo | 161 | 361.0 | 2013-2014 | |
| 77. | Robert Simmons | 160 | 450.0 | 2009-2011 | |
| 78. | Shirley Boles | 153 | 402.0 | 2013-2014 | |
| Corey Sallee | 153 | 446.0 | 2009-2013 | ||
| 80. | George Crispin | 148 | 412.0 | 2009-2014 | |
| 81. | Michael Sthilaire | 142 | 369.3 | 2009-2012 | |
| 82. | Jose Valencia | 135 | 385.9 | 2009-2014 | |
| 83. | Brandon Frazier | 132 | 370.0 | 2011-2011 | |
| 84. | Lloyd Brooks | 128 | 391.0 | 2009-2014 | |
| 85. | Lester Ehmann | 119 | 376.0 | 2009-2014 | |
| Larry Galusha | 119 | 342.0 | 2013-2014 | ||
| 87. | Mark Pacheco | 115 | 374.7 | 2011-2014 | |
| 88. | Pablo Hernandez | 106 | 257.7 | 2009-2013 | |
| 89. | Bill Falgout | 104 | 281.7 | 2009-2014 | |
| Frank Bareche | 104 | 298.3 | 2009-2009 | ||
| 91. | Carmine Ryan | 98 | 261.0 | 2013-2013 | |
| 92. | James Camara | 97 | 355.0 | 2012-2014 | |
| 93. | Roland Palen | 94 | 238.7 | 2013-2014 | |
| 94. | William Bourland | 92 | 274.0 | 2009-2014 | |
| Isaac Hipp | 92 | 230.0 | 2014-2014 | ||
| Isojuurou Tomoyuki | 92 | 211.0 | 2009-2011 | ||
| 97. | Adam Easterly | 88 | 235.7 | 2009-2014 | |
| 98. | Wilson Dejesus | 82 | 217.0 | 2014-2014 | |
| 99. | Darnell Millican | 80 | 182.3 | 2010-2010 | |
| 100. | Javy Fernandez | 72 | 218.3 | 2012-2014 |
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