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| Second Basemen Career Homeruns Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Homeruns | PA | Years | Single Season Leaderboard |
| 1. | Daniel Walker | 117 | 3610 | 2009-2014 | |
| 2. | Lucas Espitia | 102 | 4290 | 2009-2014 | |
| 3. | Alberto Andrade | 90 | 3344 | 2009-2014 | |
| 4. | Daniel Blaha | 89 | 3751 | 2009-2014 | |
| 5. | Jeremy Phillips | 86 | 3717 | 2009-2014 | |
| 6. | Michael Larson | 81 | 3498 | 2010-2014 | |
| 7. | Arnold Harkins | 77 | 3465 | 2009-2014 | |
| 8. | Michael Beckley | 76 | 3846 | 2009-2014 | |
| 9. | Rayford Azevedo | 69 | 3513 | 2009-2014 | |
| 10. | Raimundo Ramirez | 65 | 3077 | 2009-2014 | |
| 11. | Steven Cameron | 50 | 2132 | 2011-2014 | |
| Tokukichirou Shigematsu | 50 | 2572 | 2009-2013 | ||
| 13. | Richard Mowers | 47 | 2279 | 2010-2014 | |
| Ferdy Diaz | 47 | 2031 | 2009-2012 | ||
| 15. | Herb Wells | 46 | 1976 | 2010-2014 | |
| Harold Bates | 46 | 1558 | 2012-2014 | ||
| 17. | Ramon Serrano | 43 | 3934 | 2009-2014 | |
| Faustino Delmas | 43 | 2614 | 2010-2014 | ||
| Alvin Kelley | 43 | 1714 | 2009-2013 | ||
| 20. | Randy Crofts | 42 | 1588 | 2009-2012 | |
| 21. | Jose Luna | 41 | 2458 | 2009-2013 | |
| 22. | Thomas Grandstaff | 35 | 1570 | 2011-2014 | |
| Duane Fuller | 35 | 677 | 2014-2014 | ||
| Andres Herrera | 35 | 1231 | 2009-2010 | ||
| 25. | Kevin Yuko | 31 | 2389 | 2009-2014 | |
| 26. | Matthew Fout | 28 | 2840 | 2009-2014 | |
| 27. | Paul Tapia | 27 | 3764 | 2009-2014 | |
| Kenneth Coghlan | 27 | 1501 | 2009-2012 | ||
| 29. | Ben Mora | 22 | 1210 | 2009-2014 | |
| Walter Ocejo | 22 | 2964 | 2009-2013 | ||
| Corey Sallee | 22 | 698 | 2009-2013 | ||
| 32. | Faustino Rodarte | 21 | 2768 | 2009-2013 | |
| 33. | Charles Stanhope | 20 | 657 | 2013-2014 | |
| 34. | Antonio Escarcega | 19 | 1541 | 2009-2014 | |
| Stephen Allison | 19 | 780 | 2013-2014 | ||
| Paul Mielke | 19 | 777 | 2013-2014 | ||
| Leroy Judah | 19 | 717 | 2010-2012 | ||
| 38. | Hernan Colomo | 17 | 497 | 2013-2014 | |
| 39. | Barry Russo | 16 | 856 | 2013-2014 | |
| 40. | Timothy Condron | 15 | 1306 | 2009-2014 | |
| Horace Shockey | 15 | 1212 | 2009-2013 | ||
| 42. | Ronaldo Triado | 13 | 774 | 2009-2010 | |
| 43. | Willie Velazquez | 12 | 527 | 2011-2014 | |
| Cirilo Garcia | 12 | 706 | 2009-2010 | ||
| 45. | Frederick Celestin | 11 | 1742 | 2009-2014 | |
| Javier Amezaga | 11 | 981 | 2009-2014 | ||
| Michael Sthilaire | 11 | 616 | 2009-2012 | ||
| 48. | Pedro Carrasquillo | 10 | 328 | 2013-2014 | |
| Ulises Fontaņez | 10 | 745 | 2009-2010 | ||
| 50. | James Gould | 9 | 543 | 2012-2014 | |
| Matthew Estabrook | 9 | 866 | 2009-2013 | ||
| 52. | James Camara | 8 | 575 | 2012-2014 | |
| Larry Galusha | 8 | 333 | 2010-2014 | ||
| Ricky Williams | 8 | 889 | 2009-2013 | ||
| Isojuurou Tomoyuki | 8 | 339 | 2009-2011 | ||
| Eric Farthing | 8 | 959 | 2009-2010 | ||
| 57. | Valentine Turbeville | 6 | 543 | 2010-2013 | |
| 58. | Erubiel Vela | 5 | 1152 | 2010-2014 | |
| Brandon Frazier | 5 | 165 | 2011-2011 | ||
| Peter Rausch | 5 | 219 | 2009-2010 | ||
| 61. | Kenneth Downey | 4 | 553 | 2014-2014 | |
| Ralph Turner | 4 | 425 | 2014-2014 | ||
| 63. | Billy Gold | 3 | 119 | 2014-2014 | |
| Kevin Nicastro | 3 | 735 | 2009-2012 | ||
| Darnell Millican | 3 | 79 | 2009-2010 | ||
| Frank Bareche | 3 | 403 | 2009-2009 | ||
| Jose Martin | 3 | 126 | 2009-2009 | ||
| 68. | Mark Pacheco | 2 | 626 | 2011-2014 | |
| Hans Armstrong | 2 | 329 | 2014-2014 | ||
| Shirley Boles | 2 | 239 | 2013-2014 | ||
| Steven Grillo | 2 | 507 | 2009-2012 | ||
| Zacarias Morales | 2 | 48 | 2009-2009 | ||
| 73. | Roland Palen | 1 | 134 | 2013-2014 | |
| Tony Gingras | 1 | 143 | 2013-2013 | ||
| James Marine | 1 | 120 | 2009-2010 | ||
| Samuel Montoya | 1 | 189 | 2009-2009 |
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