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| Career Strikeouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts | PA | Years | Single Season Leaderboard |
| 1. | Kenny Blumberg | 894 | 3979 | 2009-2014 | |
| 2. | Buster Tate | 878 | 3555 | 2009-2014 | |
| 3. | Melchor Coronado | 874 | 3482 | 2009-2014 | |
| 4. | Jose Zena | 861 | 3669 | 2009-2014 | |
| 5. | Leroy Mankin | 854 | 3335 | 2009-2014 | |
| 6. | Luis Franco | 841 | 3905 | 2009-2014 | |
| 7. | Jeremy Phillips | 820 | 3717 | 2009-2014 | |
| 8. | Russ Barrett | 803 | 3892 | 2009-2014 | |
| 9. | John Strasser | 790 | 3483 | 2009-2014 | |
| 10. | Walker McElfresh | 747 | 4143 | 2009-2014 | |
| 11. | Eddie Meas | 746 | 3764 | 2009-2014 | |
| 12. | Ernest Crivello | 735 | 3187 | 2009-2014 | |
| 13. | Keith Smith | 732 | 3863 | 2009-2014 | |
| 14. | Pedro Vizcaino | 729 | 3255 | 2009-2014 | |
| 15. | Wilbert Prager | 720 | 3179 | 2009-2013 | |
| 16. | Jaime Armas | 719 | 3360 | 2009-2014 | |
| 17. | Ramon Serrano | 705 | 3934 | 2009-2014 | |
| 18. | Bill Souder | 700 | 3881 | 2009-2014 | |
| Faustino Rodarte | 700 | 2768 | 2009-2013 | ||
| 20. | Michael Davis | 699 | 3435 | 2009-2014 | |
| 21. | Emil Villarreal | 696 | 3020 | 2009-2014 | |
| 22. | Marvin Delvecchio | 683 | 3744 | 2009-2014 | |
| 23. | Willie Johnson | 678 | 3699 | 2009-2014 | |
| 24. | Troy Aki | 674 | 3341 | 2009-2014 | |
| 25. | Arnoldo Alvarado | 670 | 3528 | 2009-2014 | |
| 26. | Maiku Inejiro | 667 | 3631 | 2009-2014 | |
| 27. | Bryan Riggs | 664 | 3608 | 2009-2014 | |
| 28. | Daniel Walker | 655 | 3610 | 2009-2014 | |
| 29. | Paul Tapia | 635 | 3764 | 2009-2014 | |
| 30. | Dominick Lund | 631 | 4094 | 2009-2014 | |
| 31. | Matthew Shaner | 629 | 3341 | 2009-2014 | |
| Allen Hepner | 629 | 3235 | 2009-2014 | ||
| 33. | Jaime Gonzalez | 622 | 4114 | 2009-2014 | |
| 34. | Sang Aleshire | 618 | 3893 | 2009-2014 | |
| 35. | Mathew Skinner | 615 | 3851 | 2009-2014 | |
| 36. | Bryce Alexander | 611 | 3612 | 2009-2014 | |
| 37. | Blake Hamilton | 609 | 4020 | 2009-2014 | |
| 38. | Alejo Ramirez | 606 | 3985 | 2009-2014 | |
| 39. | Palmer Amico | 603 | 2917 | 2009-2014 | |
| 40. | Jl Perez | 599 | 3476 | 2009-2014 | |
| 41. | Jacob Northcutt | 598 | 3402 | 2009-2014 | |
| 42. | Osvaldo Lueras | 595 | 3597 | 2009-2014 | |
| 43. | Michael Bailey | 592 | 3507 | 2009-2014 | |
| 44. | Taitarou Haranobu | 590 | 4083 | 2009-2014 | |
| Eugene Pelzer | 590 | 3140 | 2009-2014 | ||
| 46. | Mike Chisholm | 588 | 3863 | 2009-2014 | |
| 47. | Bill Coldiron | 587 | 3622 | 2009-2014 | |
| 48. | Bill Falco | 584 | 3338 | 2009-2014 | |
| 49. | Guy Gillham | 583 | 3819 | 2009-2014 | |
| 50. | Eddie House | 581 | 3658 | 2009-2014 | |
| 51. | Arnold Harkins | 579 | 3465 | 2009-2014 | |
| 52. | Willie Sullivan | 577 | 3743 | 2009-2014 | |
| 53. | Joseph Biller | 575 | 2822 | 2009-2014 | |
| 54. | Daniel Blaha | 573 | 3751 | 2009-2014 | |
| 55. | Tomas Nelson | 570 | 3643 | 2009-2014 | |
| 56. | Ray Barrot | 569 | 2552 | 2011-2014 | |
| 57. | Alberto Andrade | 565 | 3344 | 2009-2014 | |
| 58. | Manuel Ciles | 563 | 3795 | 2009-2014 | |
| 59. | Douglas Linsley | 562 | 3243 | 2009-2014 | |
| 60. | Bill Falgout | 561 | 2537 | 2009-2014 | |
| 61. | Serafin Fradera | 559 | 3938 | 2009-2014 | |
| 62. | Glenn Knapp | 558 | 4130 | 2009-2014 | |
| Arthur Kohei | 558 | 3783 | 2009-2014 | ||
| 64. | Glenn Carrozza | 557 | 3691 | 2009-2014 | |
| 65. | Elias Mohamed | 554 | 3016 | 2009-2013 | |
| 66. | Cane Wilson | 553 | 2604 | 2009-2014 | |
| 67. | James Baker | 552 | 3553 | 2009-2014 | |
| Mario Witty | 552 | 2939 | 2010-2014 | ||
| 69. | Ronald Ono | 550 | 3479 | 2009-2014 | |
| 70. | Gregory Scroggins | 543 | 2226 | 2009-2014 | |
| 71. | Joseph Montoya | 538 | 3533 | 2009-2014 | |
| 72. | Claver Tafoya | 537 | 3153 | 2010-2014 | |
| 73. | James Jenning | 536 | 3864 | 2009-2014 | |
| Ignacio Cordero | 536 | 3695 | 2009-2014 | ||
| 75. | Santiago Hernandez | 533 | 2833 | 2010-2014 | |
| 76. | Edward Vizcaino | 531 | 2494 | 2009-2013 | |
| 77. | James Mahaffey | 527 | 4070 | 2009-2014 | |
| 78. | Rayford Azevedo | 525 | 3513 | 2009-2014 | |
| Jacobo Escarcega | 525 | 3163 | 2009-2014 | ||
| 80. | Omar Velazquez | 523 | 2340 | 2009-2014 | |
| 81. | Rogelio Ramirez | 519 | 2984 | 2009-2014 | |
| 82. | Daryl Ryles | 513 | 4035 | 2009-2014 | |
| 83. | Walter Ocejo | 511 | 2964 | 2009-2013 | |
| 84. | Lucas Espitia | 509 | 4290 | 2009-2014 | |
| 85. | James Randell | 506 | 3182 | 2009-2014 | |
| 86. | Raul Delao | 503 | 2698 | 2009-2014 | |
| Ferdy Diaz | 503 | 2031 | 2009-2012 | ||
| 88. | John Athey | 497 | 2859 | 2009-2013 | |
| 89. | Ted Pauling | 496 | 3019 | 2009-2014 | |
| 90. | Patrick Winders | 494 | 2835 | 2009-2014 | |
| 91. | John Mitchell | 493 | 2393 | 2009-2014 | |
| 92. | Raimundo Ramirez | 491 | 3077 | 2009-2014 | |
| 93. | Michael Larson | 490 | 3498 | 2010-2014 | |
| 94. | Johnathan Conte | 489 | 2324 | 2009-2013 | |
| 95. | Robert Glynn | 487 | 2040 | 2009-2014 | |
| 96. | Aran Takafumi | 485 | 3286 | 2009-2014 | |
| Salvador Peralta | 485 | 2949 | 2009-2014 | ||
| 98. | Luther Eugene | 484 | 2645 | 2009-2014 | |
| 99. | Oswaldo Basaldua | 483 | 2449 | 2009-2013 | |
| 100. | Jeremy Bevill | 480 | 2648 | 2009-2014 |
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